Skip Navigation


Biostatistics Advance Access originally published online on April 14, 2005
Biostatistics 2005 6(3):395-403; doi:10.1093/biostatistics/kxi017
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
6/3/395    most recent
kxi017v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Byth, K.
Right arrow Articles by Cox, D. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Byth, K.
Right arrow Articles by Cox, D. R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org.

On the relation between initial value and slope

K. Byth*

NHMRC Clinical Trials Centre, University of Sydney, Locked Bag 77, Camperdown, NSW 1450, Australia and Westmead Millenium Institute, Westmead Hospital, Westmead, NSW 2145, Australia. kbyth{at}ctc.usyd.edu.au

D. R. Cox

Nuffield College, Oxford, OX1 1NF, UK

* To whom correspondence should be addressed.

Suppose measurements of a particular feature are collected at baseline and at a number of subsequent time points and that for each individual there is a roughly linear trend in time. This paper takes three approaches to testing whether there is a relation between the initial value and the slope. It also considers whether the initial value for an individual is a useful predictor of the slope for that individual. The problems are formulated in terms of regression models with random coefficients. The solutions are illustrated using data from an observational study of clinical correlates of disability and progression in Huntington's disease.

Keywords: Huntington's disease; Initial value; Longitudinal data; Regression model with random coefficients; Regression to the mean; Slope


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
S.D. Fleming, R.S. Ilad, A-M.G. Griffin, Y. Wu, K.J. Ong, H.C. Smith, and R.J. Aitken
Prospective controlled trial of an electrophoretic method of sperm preparation for assisted reproduction: comparison with density gradient centrifugation
Hum. Reprod., December 1, 2008; 23(12): 2646 - 2651.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.