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Biostatistics Advance Access published online on April 20, 2005
Biostatistics, doi:10.1093/biostatistics/kxi026
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© The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org.
Received September 23, 2004
Revised March 9, 2005
Accepted April 11, 2005

Article

Generalized Spatial Structural Equation Models

Xuan Liu 1*, Melanie M. Wall 1, and James S. Hodges 1

1 Division of Biostatistics, School of Public Health, University of Minnesota, MMC 303, Minneapolis, Minnesota 55455, U.S.A.

* To whom correspondence should be addressed.
Xuan Liu, E-mail: xuanliu{at}biostat.umn.edu


  Abstract

It is common in public health research to have high dimensional, multivariate, spatially-referenced data representing summaries of geographic regions. Often it is desirable to examine relationships among these variables both within and across regions. An existing modeling technique called spatial factor analysis has been used and assumes that a common spatial factor underlies all the variables and causes them to be related to one another. An extension of this technique considers that there may be more than one underlying factor, and that relationships among the underlying latent variables are of primary interest. However, due to the complicated nature of the covariance structure of this type of data, existing methods are not satisfactory. We thus propose a generalized spatial structural equation model (GSSEM). In the first level of the model, we assume the observed variables are related to particular underlying factors. In the second level of the model, we use the structural equation method to model the relationship among the underlying factors and use parametric spatial distributions on the covariance structure of the underlying factors. We apply the model to county-level cancer mortality and census summary data for Minnesota, including socioeconomic status and access to public utilities.


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