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Biostatistics Advance Access published online on April 5, 2006
Biostatistics, doi:10.1093/biostatistics/kxj028
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© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org
Received March 31, 2005
Revised January 27, 2006
Accepted March 8, 2006

Article

Parametric survival models for interval censored data with time-dependent covariates

Yvonne H. Sparling 1, Naji Younes 1, Oliver M. Bautista 2, and John M. Lachin 1 *

1 The Biostatistics Center, Department of Biostatistics and Epidemiology, School of Public Health and Health Services, The George Washington University, 6110 Executive Boulevard, Suite 750, Rockville, Maryland USA 20852
2 Merck and Company, Blue Bell, PA 19422

* To whom correspondence should be addressed.
John M. Lachin, E-mail: jml{at}biostat.bsc.gwu.edu


  Abstract

We present a parametric family of regression models for interval-censored event-time (survival) data that accomodates both fixed (e.g. baseline) and time-dependent covariates. The model employs a three-parameter family of survival distributions that includes the Weibull, negative binomial and log-logistic distributions as special cases, and can be applied to data with left, right, interval, or non-censored event times. Standard methods, such as Newton-Raphson can be employed to estimate the model and the resulting estimates have an asymptotically normal distribution about the true values with a covariance matrix that is consistently estimated by the information function. The deviance function is described to assess model fit and a robust sandwich estimate of the covariance may also be employed to provide asymptotically robust inferences when the model assumptions do not apply. Spline functions may also be employed to allow for non-linear covariates. The model is applied to data from a long-term study of type 1 diabetes to describe the effects of longitudinal measures of glycemia (HbA1c) over time (the time-dependent covariate) on the risk of progression of diabetic retinopathy (eye disease), an interval-censored event-time outcome.

Keywords: Interval-censored data; parametric models; time-dependent covariates.
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